Cargando…
Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome
Gut dysbiosis in Huntington's disease (HD) has recently been reported using microbiome profiling in R6/1 HD mice and replicated in clinical HD. In HD mice, environmental enrichment (EE) and exercise (EX) were shown to have therapeutic impacts on the brain and associated symptoms. We hypothesize...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760441/ https://www.ncbi.nlm.nih.gov/pubmed/35059604 http://dx.doi.org/10.1016/j.isci.2021.103687 |
_version_ | 1784633321103294464 |
---|---|
author | Gubert, Carolina Love, Chloe Jane Kodikara, Saritha Mei Liew, Jamie Jie Renoir, Thibault Lê Cao, Kim-Anh Hannan, Anthony John |
author_facet | Gubert, Carolina Love, Chloe Jane Kodikara, Saritha Mei Liew, Jamie Jie Renoir, Thibault Lê Cao, Kim-Anh Hannan, Anthony John |
author_sort | Gubert, Carolina |
collection | PubMed |
description | Gut dysbiosis in Huntington's disease (HD) has recently been reported using microbiome profiling in R6/1 HD mice and replicated in clinical HD. In HD mice, environmental enrichment (EE) and exercise (EX) were shown to have therapeutic impacts on the brain and associated symptoms. We hypothesize that these housing interventions modulate the gut microbiome, configuring one of the mechanisms that mediate their therapeutic effects observed in HD. We exposed R6/1 mice to a protocol of either EE or EX, relative to standard-housed control conditions, before the onset of gut dysbiosis and motor deficits. We characterized gut structure and function, as well as gut microbiome profiling using 16S rRNA sequencing. Multivariate analysis identified specific orders, namely Bacteroidales, Lachnospirales and Oscillospirales, as the main bacterial signatures that discriminate between housing conditions. Our findings suggest a promising role for the gut microbiome in mediating the effects of EE and EX exposures, and possibly other environmental interventions, in HD mice. |
format | Online Article Text |
id | pubmed-8760441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-87604412022-01-19 Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome Gubert, Carolina Love, Chloe Jane Kodikara, Saritha Mei Liew, Jamie Jie Renoir, Thibault Lê Cao, Kim-Anh Hannan, Anthony John iScience Article Gut dysbiosis in Huntington's disease (HD) has recently been reported using microbiome profiling in R6/1 HD mice and replicated in clinical HD. In HD mice, environmental enrichment (EE) and exercise (EX) were shown to have therapeutic impacts on the brain and associated symptoms. We hypothesize that these housing interventions modulate the gut microbiome, configuring one of the mechanisms that mediate their therapeutic effects observed in HD. We exposed R6/1 mice to a protocol of either EE or EX, relative to standard-housed control conditions, before the onset of gut dysbiosis and motor deficits. We characterized gut structure and function, as well as gut microbiome profiling using 16S rRNA sequencing. Multivariate analysis identified specific orders, namely Bacteroidales, Lachnospirales and Oscillospirales, as the main bacterial signatures that discriminate between housing conditions. Our findings suggest a promising role for the gut microbiome in mediating the effects of EE and EX exposures, and possibly other environmental interventions, in HD mice. Elsevier 2021-12-24 /pmc/articles/PMC8760441/ /pubmed/35059604 http://dx.doi.org/10.1016/j.isci.2021.103687 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gubert, Carolina Love, Chloe Jane Kodikara, Saritha Mei Liew, Jamie Jie Renoir, Thibault Lê Cao, Kim-Anh Hannan, Anthony John Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome |
title | Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome |
title_full | Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome |
title_fullStr | Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome |
title_full_unstemmed | Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome |
title_short | Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome |
title_sort | gene-environment-gut interactions in huntington's disease mice are associated with environmental modulation of the gut microbiome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760441/ https://www.ncbi.nlm.nih.gov/pubmed/35059604 http://dx.doi.org/10.1016/j.isci.2021.103687 |
work_keys_str_mv | AT gubertcarolina geneenvironmentgutinteractionsinhuntingtonsdiseasemiceareassociatedwithenvironmentalmodulationofthegutmicrobiome AT lovechloejane geneenvironmentgutinteractionsinhuntingtonsdiseasemiceareassociatedwithenvironmentalmodulationofthegutmicrobiome AT kodikarasaritha geneenvironmentgutinteractionsinhuntingtonsdiseasemiceareassociatedwithenvironmentalmodulationofthegutmicrobiome AT meiliewjamiejie geneenvironmentgutinteractionsinhuntingtonsdiseasemiceareassociatedwithenvironmentalmodulationofthegutmicrobiome AT renoirthibault geneenvironmentgutinteractionsinhuntingtonsdiseasemiceareassociatedwithenvironmentalmodulationofthegutmicrobiome AT lecaokimanh geneenvironmentgutinteractionsinhuntingtonsdiseasemiceareassociatedwithenvironmentalmodulationofthegutmicrobiome AT hannananthonyjohn geneenvironmentgutinteractionsinhuntingtonsdiseasemiceareassociatedwithenvironmentalmodulationofthegutmicrobiome |