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Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome

Gut dysbiosis in Huntington's disease (HD) has recently been reported using microbiome profiling in R6/1 HD mice and replicated in clinical HD. In HD mice, environmental enrichment (EE) and exercise (EX) were shown to have therapeutic impacts on the brain and associated symptoms. We hypothesize...

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Autores principales: Gubert, Carolina, Love, Chloe Jane, Kodikara, Saritha, Mei Liew, Jamie Jie, Renoir, Thibault, Lê Cao, Kim-Anh, Hannan, Anthony John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760441/
https://www.ncbi.nlm.nih.gov/pubmed/35059604
http://dx.doi.org/10.1016/j.isci.2021.103687
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author Gubert, Carolina
Love, Chloe Jane
Kodikara, Saritha
Mei Liew, Jamie Jie
Renoir, Thibault
Lê Cao, Kim-Anh
Hannan, Anthony John
author_facet Gubert, Carolina
Love, Chloe Jane
Kodikara, Saritha
Mei Liew, Jamie Jie
Renoir, Thibault
Lê Cao, Kim-Anh
Hannan, Anthony John
author_sort Gubert, Carolina
collection PubMed
description Gut dysbiosis in Huntington's disease (HD) has recently been reported using microbiome profiling in R6/1 HD mice and replicated in clinical HD. In HD mice, environmental enrichment (EE) and exercise (EX) were shown to have therapeutic impacts on the brain and associated symptoms. We hypothesize that these housing interventions modulate the gut microbiome, configuring one of the mechanisms that mediate their therapeutic effects observed in HD. We exposed R6/1 mice to a protocol of either EE or EX, relative to standard-housed control conditions, before the onset of gut dysbiosis and motor deficits. We characterized gut structure and function, as well as gut microbiome profiling using 16S rRNA sequencing. Multivariate analysis identified specific orders, namely Bacteroidales, Lachnospirales and Oscillospirales, as the main bacterial signatures that discriminate between housing conditions. Our findings suggest a promising role for the gut microbiome in mediating the effects of EE and EX exposures, and possibly other environmental interventions, in HD mice.
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spelling pubmed-87604412022-01-19 Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome Gubert, Carolina Love, Chloe Jane Kodikara, Saritha Mei Liew, Jamie Jie Renoir, Thibault Lê Cao, Kim-Anh Hannan, Anthony John iScience Article Gut dysbiosis in Huntington's disease (HD) has recently been reported using microbiome profiling in R6/1 HD mice and replicated in clinical HD. In HD mice, environmental enrichment (EE) and exercise (EX) were shown to have therapeutic impacts on the brain and associated symptoms. We hypothesize that these housing interventions modulate the gut microbiome, configuring one of the mechanisms that mediate their therapeutic effects observed in HD. We exposed R6/1 mice to a protocol of either EE or EX, relative to standard-housed control conditions, before the onset of gut dysbiosis and motor deficits. We characterized gut structure and function, as well as gut microbiome profiling using 16S rRNA sequencing. Multivariate analysis identified specific orders, namely Bacteroidales, Lachnospirales and Oscillospirales, as the main bacterial signatures that discriminate between housing conditions. Our findings suggest a promising role for the gut microbiome in mediating the effects of EE and EX exposures, and possibly other environmental interventions, in HD mice. Elsevier 2021-12-24 /pmc/articles/PMC8760441/ /pubmed/35059604 http://dx.doi.org/10.1016/j.isci.2021.103687 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gubert, Carolina
Love, Chloe Jane
Kodikara, Saritha
Mei Liew, Jamie Jie
Renoir, Thibault
Lê Cao, Kim-Anh
Hannan, Anthony John
Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome
title Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome
title_full Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome
title_fullStr Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome
title_full_unstemmed Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome
title_short Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome
title_sort gene-environment-gut interactions in huntington's disease mice are associated with environmental modulation of the gut microbiome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760441/
https://www.ncbi.nlm.nih.gov/pubmed/35059604
http://dx.doi.org/10.1016/j.isci.2021.103687
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