Mechanistic details of the actinobacterial lyase-catalyzed degradation reaction of 2-hydroxyisobutyryl-CoA

Actinobacterial 2-hydroxyacyl-CoA lyase reversibly catalyzes the thiamine diphosphate-dependent cleavage of 2-hydroxyisobutyryl-CoA to formyl-CoA and acetone. This enzyme has great potential for use in synthetic one-carbon assimilation pathways for sustainable production of chemicals, but lacks deta...

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Detalles Bibliográficos
Autores principales: Zahn, Michael, König, Gerhard, Pham, Huy Viet Cuong, Seroka, Barbara, Lazny, Ryszard, Yang, Guangli, Ouerfelli, Ouathek, Lotowski, Zenon, Rohwerder, Thore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760513/
https://www.ncbi.nlm.nih.gov/pubmed/34952003
http://dx.doi.org/10.1016/j.jbc.2021.101522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760513/
https://www.ncbi.nlm.nih.gov/pubmed/34952003
http://dx.doi.org/10.1016/j.jbc.2021.101522

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