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Incidental germline findings during molecular profiling of tumor tissues for precision oncology: molecular survey and methodological obstacles
BACKGROUND: A fraction of patients referred for complex molecular profiling of biopsied tumors may harbor germline variants in genes associated with the development of hereditary cancer syndromes (HCS). Neither the bioinformatic analysis nor the reporting of such incidental germline findings are sta...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760669/ https://www.ncbi.nlm.nih.gov/pubmed/35033101 http://dx.doi.org/10.1186/s12967-022-03230-z |