Incidental germline findings during molecular profiling of tumor tissues for precision oncology: molecular survey and methodological obstacles

BACKGROUND: A fraction of patients referred for complex molecular profiling of biopsied tumors may harbor germline variants in genes associated with the development of hereditary cancer syndromes (HCS). Neither the bioinformatic analysis nor the reporting of such incidental germline findings are sta...

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Detalles Bibliográficos
Autores principales: Lebedeva, Alexandra, Shaykhutdinova, Yulia, Seriak, Daria, Ignatova, Ekaterina, Rozhavskaya, Ekaterina, Vardhan, Divyasphoorthi, Manicka, Sofia, Sharova, Margarita, Grigoreva, Tatiana, Baranova, Ancha, Mileyko, Vladislav, Ivanov, Maxim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760669/
https://www.ncbi.nlm.nih.gov/pubmed/35033101
http://dx.doi.org/10.1186/s12967-022-03230-z

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