The dominant TP53 hotspot mutation in IDH-mutant astrocytoma, R273C, has distinctive pathologic features and sex-specific prognostic implications

BACKGROUND: Infiltrative astrocytic tumors with and without isocitrate dehydrogenase (IDH) mutation frequently contain mutations in the TP53 tumor suppressor gene. Disruption of normal p53 protein activity confers neoplastic cells with a number of oncogenic properties and is a common feature of aggr...

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Detalles Bibliográficos
Autores principales: Marker, Daniel F, Agnihotri, Sameer, Amankulor, Nduka, Murdoch, Geoffrey H, Pearce, Thomas M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Clinical Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760900/
https://www.ncbi.nlm.nih.gov/pubmed/35047821
http://dx.doi.org/10.1093/noajnl/vdab182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760900/
https://www.ncbi.nlm.nih.gov/pubmed/35047821
http://dx.doi.org/10.1093/noajnl/vdab182

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