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Physiological clearance of Aβ by spleen and splenectomy aggravates Alzheimer‐type pathogenesis
BACKGROUND: A previous study demonstrated that nearly 40%–60% of brain Aβ flows out into the peripheral system for clearance. However, where and how circulating Aβ is cleared in the periphery remains unclear. The spleen acts as a blood filter and an immune organ. The aim of the present study was to...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761003/ https://www.ncbi.nlm.nih.gov/pubmed/34939734 http://dx.doi.org/10.1111/acel.13533 |