Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

The increase in senescent cells in tissues, including the brain, is a general feature of normal aging and age‐related pathologies. Senescent cells exhibit a specific phenotype, which includes an altered nuclear morphology and transcriptomic changes. Astrocytes undergo senescence in vitro and in age‐...

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Detalles Bibliográficos
Autores principales: Matias, Isadora, Diniz, Luan Pereira, Damico, Isabella Vivarini, Araujo, Ana Paula Bergamo, Neves, Laís da Silva, Vargas, Gabriele, Leite, Renata E. P., Suemoto, Claudia K., Nitrini, Ricardo, Jacob‐Filho, Wilson, Grinberg, Lea T., Hol, Elly M., Middeldorp, Jinte, Gomes, Flávia Carvalho Alcantara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761005/
https://www.ncbi.nlm.nih.gov/pubmed/34894056
http://dx.doi.org/10.1111/acel.13521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761005/
https://www.ncbi.nlm.nih.gov/pubmed/34894056
http://dx.doi.org/10.1111/acel.13521

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