Cargando…
Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics
Aging and senescence impact CD4 T helper cell (Th) subset differentiation during influenza infection. In the lungs of infected aged mice, there were significantly greater percentages of Th cells expressing the transcription factor FoxP3, indicative of regulatory CD4 T cells (Treg), when compared to...
Autores principales: | Lorenzo, Erica C., Torrance, Blake L., Keilich, Spencer R., Al‐Naggar, Iman, Harrison, Andrew, Xu, Ming, Bartley, Jenna M., Haynes, Laura |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761018/ https://www.ncbi.nlm.nih.gov/pubmed/34962049 http://dx.doi.org/10.1111/acel.13525 |
Ejemplares similares
-
Vaccination Improves CD4 T Helper Subset Balance in Aged Mice by Overcoming the Effects of the Senescent Environment
por: Torrance, Blake, et al.
Publicado: (2020) -
Impact of senolytic treatment on immunity, aging, and disease
por: Lorenzo, Erica C., et al.
Publicado: (2023) -
Senolytic treatment with dasatinib and quercetin does not improve overall influenza responses in aged mice
por: Torrance, Blake L., et al.
Publicado: (2023) -
P16-EXPRESSING SENESCENT CELLS ARE A DOUBLE-EDGED SWORD IN SHAPING IMMUNE RESPONSES WITH AGE
por: Torrance, Blake, et al.
Publicado: (2022) -
Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy
por: Bartley, Jenna M., et al.
Publicado: (2016)