Chemically induced senescence in human stem cell‐derived neurons promotes phenotypic presentation of neurodegeneration

Modeling age‐related neurodegenerative disorders with human stem cells are difficult due to the embryonic nature of stem cell‐derived neurons. We developed a chemical cocktail to induce senescence of iPSC‐derived neurons to address this challenge. We first screened small molecules that induce embryo...

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Detalles Bibliográficos
Autores principales: Fathi, Ali, Mathivanan, Sakthikumar, Kong, Linghai, Petersen, Andrew J., Harder, Cole R. K., Block, Jasper, Miller, Julia Marie, Bhattacharyya, Anita, Wang, Daifeng, Zhang, Su‐Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761019/
https://www.ncbi.nlm.nih.gov/pubmed/34953016
http://dx.doi.org/10.1111/acel.13541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761019/
https://www.ncbi.nlm.nih.gov/pubmed/34953016
http://dx.doi.org/10.1111/acel.13541

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