Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells

Loss of alveolar type 2 cells (AEC2s) and ectopic appearance of basal cells in the alveoli characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we demonstrate that human alveolar type 2 cells (hAEC2s), unlike murine AEC2s, transdifferentiate into basal cells in respons...

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Detalles Bibliográficos
Autores principales: Kathiriya, Jaymin J., Wang, Chaoqun, Zhou, Minqi, Brumwell, Alexis, Cassandras, Monica, Le Saux, Claude, Cohen, Max, Alysandratos, Kostantinos-Dionysios, Wang, Bruce, Wolters, Paul, Matthay, Michael, Kotton, Darrell N., Chapman, Harold A, Peng, Tien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761168/
https://www.ncbi.nlm.nih.gov/pubmed/34969962
http://dx.doi.org/10.1038/s41556-021-00809-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761168/
https://www.ncbi.nlm.nih.gov/pubmed/34969962
http://dx.doi.org/10.1038/s41556-021-00809-4

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