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Securin overexpression correlates with the activated Rb/E2F1 pathway and histone H3 epigenetic modifications in raw areca nut-induced carcinogenesis in mice
BACKGROUND: Raw areca nut (RAN) consumption induces oral, esophageal and gastric cancers, which are significantly associated with the overexpression of pituitary tumor transforming gene 1/securin and chromosomal instability (CIN). An association of Securin/PTTG1 upregulation and gastric cancer in hu...
Autores principales: | Boruah, Nabamita, Singh, Chongtham Sovachandra, Swargiary, Pooja, Dkhar, Hughbert, Chatterjee, Anupam |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761315/ https://www.ncbi.nlm.nih.gov/pubmed/35033090 http://dx.doi.org/10.1186/s12935-022-02442-z |
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