Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model

In motor neurons of sporadic amyotrophic lateral sclerosis (ALS) patients, the RNA editing at the glutamine/arginine site of the GluA2 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors is defective or incomplete. As a result, AMPA receptors containing the abnormally e...

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Detalles Bibliográficos
Autores principales: Akamatsu, Megumi, Yamashita, Takenari, Teramoto, Sayaka, Huang, Zhen, Lynch, Janet, Toda, Tatsushi, Niu, Li, Kwak, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761490/
https://www.ncbi.nlm.nih.gov/pubmed/35022247
http://dx.doi.org/10.26508/lsa.202101193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761490/
https://www.ncbi.nlm.nih.gov/pubmed/35022247
http://dx.doi.org/10.26508/lsa.202101193

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