Cargando…

Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model

In motor neurons of sporadic amyotrophic lateral sclerosis (ALS) patients, the RNA editing at the glutamine/arginine site of the GluA2 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors is defective or incomplete. As a result, AMPA receptors containing the abnormally e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akamatsu, Megumi, Yamashita, Takenari, Teramoto, Sayaka, Huang, Zhen, Lynch, Janet, Toda, Tatsushi, Niu, Li, Kwak, Shin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761490/ https://www.ncbi.nlm.nih.gov/pubmed/35022247 http://dx.doi.org/10.26508/lsa.202101193

Ejemplares similares

The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice
por: Akamatsu, Megumi, et al.
Publicado: (2016)

Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons
por: Yamashita, Takenari, et al.
Publicado: (2017)

Altered Intracellular Milieu of ADAR2-Deficient Motor Neurons in Amyotrophic Lateral Sclerosis
por: Yamashita, Takenari, et al.
Publicado: (2017)

Co-Occurrence of TDP-43 Mislocalization with Reduced Activity of an RNA Editing Enzyme, ADAR2, in Aged Mouse Motor Neurons
por: Hideyama, Takuto, et al.
Publicado: (2012)

Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons
por: Yamashita, Takenari, et al.
Publicado: (2013)

One aptamer, two functions: the full-length aptamer inhibits AMPA receptors, while the short one inhibits both AMPA and kainate receptors
por: Jaremko, William J., et al.
Publicado: (2017)

One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors
por: Huang, Zhen, et al.
Publicado: (2009)

Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases
por: Hosaka, Takashi, et al.
Publicado: (2019)

Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein
por: Aizawa, Hitoshi, et al.
Publicado: (2019)

AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking
por: Bissen, Diane, et al.
Publicado: (2019)

Antigenic and mechanistic characterization of anti-AMPA receptor encephalitis
por: Gleichman, Amy J, et al.
Publicado: (2014)

Dysregulation of AMPA receptor subunit expression in sporadic ALS post‐mortem brain
por: Gregory, Jenna M, et al.
Publicado: (2019)

Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum
por: Coombs, I.D., et al.
Publicado: (2009)

Ca(2+)-permeable AMPA receptors in mouse olfactory bulb astrocytes
por: Droste, Damian, et al.
Publicado: (2017)

Subunit‐specific expression and function of AMPA receptors in the mouse locus coeruleus
por: Kelly, Louise, et al.
Publicado: (2023)

Synaptic zinc potentiates AMPA receptor function in mouse auditory cortex
por: Bender, Philip T.R., et al.
Publicado: (2023)

Reduced Effect of Anticonvulsants on AMPA Receptor Palmitoylation-Deficient Mice
por: Iizumi, Madoka, et al.
Publicado: (2021)

Uncorking AMPA receptors
por: Sedwick, Caitlin
Publicado: (2018)

Resensitizing AMPA receptors
por: Short, Ben
Publicado: (2019)

Aptamers as therapeutics
por: Keefe, Anthony D., et al.
Publicado: (2010)

Mechanism-based design of 2,3-benzodiazepine inhibitors for AMPA receptors
por: Niu, Li
Publicado: (2015)

AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model
por: Hettinger, Jane C., et al.
Publicado: (2018)

AMPA Receptor-Mediated Ca(2+) Transients in Mouse Olfactory Ensheathing Cells
por: Beiersdorfer, Antonia, et al.
Publicado: (2019)

Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons
por: Harb, Ali, et al.
Publicado: (2021)

AMPA Receptor Activation Causes Silencing of AMPA Receptor-Mediated Synaptic Transmission in the Developing Hippocampus
por: Wasling, Pontus, et al.
Publicado: (2012)

Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome
por: Chojnacka, Magdalena, et al.
Publicado: (2023)

Therapeutic Aptamers March On
por: Weinberg, Marc S
Publicado: (2014)

An overview and future prospects on aptamers for food safety
por: Schmitz, Fernanda Raquel Wust, et al.
Publicado: (2020)

Acute Footshock Stress Induces Time-Dependent Modifications of AMPA/NMDA Protein Expression and AMPA Phosphorylation
por: Bonini, Daniela, et al.
Publicado: (2016)

Sequential Activation of AMPA Receptors and Glial Cells in a Pain Model of Lumbar Spine Disc Herniation
por: Kwak, Dong Gyu, et al.
Publicado: (2020)

Safety of Memantine in Combination with Potentially Interactive Drugs in the Real World: A Pharmacovigilance Study Using the Japanese Adverse Drug Event Report (JADER) Database
por: Sato, Kenichiro, et al.
Publicado: (2021)

Activation of AMPA Receptors in the Suprachiasmatic Nucleus Phase-Shifts the Mouse Circadian Clock In Vivo and In Vitro
por: Mizoro, Yasutaka, et al.
Publicado: (2010)

Molecular constituents of neuronal AMPA receptors
por: Fukata, Yuko, et al.
Publicado: (2005)

Calcium-Permeable AMPA Receptors in the Retina
por: Diamond, Jeffrey S.
Publicado: (2011)

Regulation of AMPA receptors in spinal nociception
por: Wang, Yun, et al.
Publicado: (2010)

Superactivation of AMPA receptors by auxiliary proteins
por: Carbone, Anna L., et al.
Publicado: (2016)

Ubiquitin signals the demise of AMPA receptors
por: Widagdo, Jocelyn, et al.
Publicado: (2015)

Recent Findings on AMPA Receptor Recycling
por: Moretto, Edoardo, et al.
Publicado: (2018)

AMPA Receptor Trafficking for Postsynaptic Potentiation
por: Park, Mikyoung
Publicado: (2018)

Mechanisms of AMPA Receptor Endosomal Sorting
por: Parkinson, Gabrielle T., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bfm6g0roqar2i383f3hg01cjst