Sumoylation of Cas9 at lysine 848 regulates protein stability and DNA binding

CRISPR/Cas9 is a popular genome editing technology. Although widely used, little is known about how this prokaryotic system behaves in humans. An unwanted consequence of eukaryotic Cas9 expression is off-target DNA binding leading to mutagenesis. Safer clinical implementation of CRISPR/Cas9 necessit...

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Detalles Bibliográficos
Autores principales: Ergünay, Tunahan, Ayhan, Özgecan, Celen, Arda B, Georgiadou, Panagiota, Pekbilir, Emre, Abaci, Yusuf T, Yesildag, Duygu, Rettel, Mandy, Sobhiafshar, Ulduz, Ogmen, Anna, Emre, NC Tolga, Sahin, Umut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761495/
https://www.ncbi.nlm.nih.gov/pubmed/35022246
http://dx.doi.org/10.26508/lsa.202101078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761495/
https://www.ncbi.nlm.nih.gov/pubmed/35022246
http://dx.doi.org/10.26508/lsa.202101078

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