Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model

Tau pathobiology has emerged as a key component underlying Alzheimer's disease (AD) progression; however, human neuronal in vitro models have struggled to recapitulate tau phenomena observed in vivo. Here, we aimed to define the minimal requirements to achieve endogenous tau aggregation in func...

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Detalles Bibliográficos
Autores principales: Manos, Justine D., Preiss, Christina N., Venkat, Nandini, Tamm, Joseph, Reinhardt, Peter, Kwon, Taekyung, Wu, Jessica, Winter, Allison D., Jahn, Thomas R., Yanamandra, Kiran, Titterton, Katherine, Karran, Eric, Langlois, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761709/
https://www.ncbi.nlm.nih.gov/pubmed/35072001
http://dx.doi.org/10.1016/j.isci.2021.103658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761709/
https://www.ncbi.nlm.nih.gov/pubmed/35072001
http://dx.doi.org/10.1016/j.isci.2021.103658

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