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Spatial and Temporal Heterogeneity of Tumor-Infiltrating Lymphocytes in Advanced Urothelial Cancer
Checkpoint inhibitors targeting PD-(L)1 induce objective responses in 20% of patients with metastatic urothelial cancer (UC). CD8(+) T cell infiltration has been proposed as a putative biomarker for response to checkpoint inhibitors. Nevertheless, data on spatial and temporal heterogeneity of tumor-...
Autores principales: | van Wilpe, Sandra, Gorris, Mark A. J., van der Woude, Lieke L., Sultan, Shabaz, Koornstra, Rutger H. T., van der Heijden, Antoine G., Gerritsen, Winald R., Simons, Michiel, de Vries, I. Jolanda M., Mehra, Niven |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761759/ https://www.ncbi.nlm.nih.gov/pubmed/35046958 http://dx.doi.org/10.3389/fimmu.2021.802877 |
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