Cargando…

O-Acetyl-GD2 as a Therapeutic Target for Breast Cancer Stem Cells

SYNOPSIS: A sugar-lipid molecule called OAcGD2 is a novel marker for breast cancer stem cells. Treatment with anti-OAcGD2 mAb8B6 may have superior anticancer efficacy by targeting cancer stem cells, thereby reducing metastasis and recurrence of cancer. BACKGROUND: Cancer stem cells (CSCs) that drive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Jing-Yan, Hung, Jung-Tung, Lin, Juway, Lo, Fei-Yun, Huang, Jing-Rong, Chiou, Shih-Pin, Wang, Ya-Hui, Lin, Ruey-Jen, Wu, Jen-Chine, Yu, John, Yu, Alice L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761789/ https://www.ncbi.nlm.nih.gov/pubmed/35046949 http://dx.doi.org/10.3389/fimmu.2021.791551

Ejemplares similares

The Multifaceted Effects of Polysaccharides Isolated from Dendrobium huoshanense on Immune Functions with the Induction of Interleukin-1 Receptor Antagonist (IL-1ra) in Monocytes
por: Lin, Juway, et al.
Publicado: (2014)

Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype
por: Liang, Yuh-Jin, et al.
Publicado: (2017)

FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding
por: Cheng, Kai-Chun, et al.
Publicado: (2019)

Co-Delivery of CPT-11 and Panobinostat with Anti-GD2 Antibody Conjugated Immunoliposomes for Targeted Combination Chemotherapy
por: Jose, Gils, et al.
Publicado: (2020)

O-acetylation of Gd3: An Enigmatic Modification Regulating Apoptosis?
por: Chen, Helen Y., et al.
Publicado: (2002)

Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy
por: Fleurence, Julien, et al.
Publicado: (2017)

Protective Role of Programmed Death 1 Ligand 1 (PD-L1)in Nonobese Diabetic Mice : The Paradox in Transgenic Models
por: Wang, Chia-Jen, et al.
Publicado: (2008)

GD3- and O-acetylated GD3-gangliosides in the GM2 synthase-deficient mouse brain and their immunohistochemical localization
por: Matsuda, Junko, et al.
Publicado: (2006)

Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside
por: Fleurence, Julien, et al.
Publicado: (2016)

Chimeric Antibody c.8B6 to O-Acetyl-GD2 Mediates the Same Efficient Anti-Neuroblastoma Effects as Therapeutic ch14.18 Antibody to GD2 without Antibody Induced Allodynia
por: Terme, Mickaël, et al.
Publicado: (2014)

Acetylation Suppresses the Proapoptotic Activity of GD3 Ganglioside
por: Malisan, Florence, et al.
Publicado: (2002)

Disruption of GM2/GD2 synthase gene resulted in overt expression of 9-O-acetyl GD3 irrespective of Tis211
por: Furukawa, Keiko, et al.
Publicado: (2008)

Role of Sialyl-O-Acetyltransferase CASD1 on GD2 Ganglioside O-Acetylation in Breast Cancer Cells
por: Cavdarli, Sumeyye, et al.
Publicado: (2021)

Utilizing Reusable Catalyst Phosphotungstic Acid for the Synthesis of Thioglycoside from Per-O-acetyl Saccharides with Microwave-Assisted and De-O-acetylation with Methanol
por: Chen, Jyun-Siao, et al.
Publicado: (2023)

Sialylation of vasorin by ST3Gal1 facilitates TGF‐β1‐mediated tumor angiogenesis and progression
por: Yeo, Hui Ling, et al.
Publicado: (2019)

GPER‐induced signaling is essential for the survival of breast cancer stem cells
por: Chan, Yu‐Tzu, et al.
Publicado: (2019)

Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells
por: Lai, Tai-Yu, et al.
Publicado: (2019)

High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma
por: Kuo, Huan-Hsien, et al.
Publicado: (2017)

Histone Deacetylase 1 Plays an Acetylation-Independent Role in Influenza A Virus Replication
por: Chen, Lin, et al.
Publicado: (2017)

Transmembrane and coiled-coil domain family 3 (TMCC3) regulates breast cancer stem cell and AKT activation
por: Wang, Ya-Hui, et al.
Publicado: (2021)

A Monoclonal Antibody to O-Acetyl-GD2 Ganglioside and Not to GD2 Shows Potent Anti-Tumor Activity without Peripheral Nervous System Cross-Reactivity
por: Alvarez-Rueda, Nidia, et al.
Publicado: (2011)

CD44v6, STn & O-GD2: promising tumor associated antigens paving the way for new targeted cancer therapies
por: Lodewijk, Iris, et al.
Publicado: (2023)

Seroprevalence Surveys for Anti-SARS-CoV-2 Antibody in Different Populations in Taiwan With Low Incidence of COVID-19 in 2020 and Severe Outbreaks of SARS in 2003
por: Tseng, Wen-Pin, et al.
Publicado: (2021)

Modulation of macrophage polarization and lung cancer cell stemness by MUC1 and development of a related small-molecule inhibitor pterostilbene
por: Huang, Wen-Chien, et al.
Publicado: (2016)

Pharmacological Activation Of Aldehyde Dehydrogenase 2 Protects Against Heatstroke-Induced Acute Lung Injury by Modulating Oxidative Stress and Endothelial Dysfunction
por: Tsai, Hsiao-Ya, et al.
Publicado: (2021)

Lysine Acetylation/Deacetylation Modification of Immune-Related Molecules in Cancer Immunotherapy
por: Ding, Peng, et al.
Publicado: (2022)

Digital TDPAC with rare earth isotope $^{169}$Yb, $^{147}$Gd, and $^{149}$Gd in Yb and Gd Doped CeO$_{2}$ and $^{147}$Gd in GdBa$_{2}$ Cu$_{3}$ O$_{7−\delta}$
por: Roeder, Jens, et al.
Publicado: (2011)

The interplay between IGF-1R signaling and Hippo-YAP in breast cancer stem cells
por: Chan, Yu-Tzu, et al.
Publicado: (2023)

Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 Ribonucleoproteins
por: Huang, Rih-Sheng, et al.
Publicado: (2020)

Modulation of IL-6 Expression by KLF4-Mediated Transactivation and PCAF-Mediated Acetylation in Sublytic C5b-9-Induced Rat Glomerular Mesangial Cells
por: Xia, Lu, et al.
Publicado: (2022)

Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography
por: Wong, Yon-Cheong, et al.
Publicado: (2018)

Chirality and Magnetocaloricity in GdFeTeO(6) as Compared to GdGaTeO(6)
por: Zvereva, Elena, et al.
Publicado: (2021)

Therapeutic efficacy of antibody-drug conjugates targeting GD2-positive tumors
por: Kalinovsky, Daniel V, et al.
Publicado: (2022)

Correction: Chimeric Antibody c.8B6 to O-Acetyl-GD2 Mediates the Same Efficient Anti-Neuroblastoma Effects as Therapeutic ch14.18 Antibody to GD2 without Antibody Induced Allodynia
Publicado: (2014)

Histone Acetylation Regulator-Mediated Acetylation Patterns Define Tumor Malignant Pathways and Tumor Microenvironment in Hepatocellular Carcinoma
por: Xu, Yuyan, et al.
Publicado: (2022)

Maintenance therapy of low-dose nivolumab, S-1, and leucovorin in metastatic pancreatic adenocarcinoma with a germline mutation of MSH6: A case report
por: Peng, Shang-Hsuan, et al.
Publicado: (2022)

PHRF1 promotes the class switch recombination of IgA in CH12F3-2A cells
por: Lee, Jin-Yu, et al.
Publicado: (2023)

Muscle Tissue Damage and Recovery After EV71 Infection Correspond to Dynamic Macrophage Phenotypes
por: Lu, Mei-Yi, et al.
Publicado: (2021)

The Expression of Toll-Like Receptor 4 mRNA in PBMCs Is Upregulated in Smokers and Decreases Upon Smoking Cessation
por: Yeh, Hsin-Yu, et al.
Publicado: (2021)

Neuroblast migration and P2Y(1) receptor mediated calcium signalling depend on 9-O-acetyl GD3 ganglioside
por: Santiago, Marcelo F, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_lo90om2taguckj2rlifh2j9odu