Targeting cancer-associated fibroblast-secreted WNT2 restores dendritic cell-mediated antitumour immunity

OBJECTIVE: Solid tumours respond poorly to immune checkpoint inhibitor (ICI) therapies. One major therapeutic obstacle is the immunosuppressive tumour microenvironment (TME). Cancer-associated fibroblasts (CAFs) are a key component of the TME and negatively regulate antitumour T-cell response. Here,...

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Detalles Bibliográficos
Autores principales: Huang, Tu-Xiong, Tan, Xiang-Yu, Huang, Hui-Si, Li, Yu-Ting, Liu, Bei-Lei, Liu, Kai-Sheng, Chen, Xinchun, Chen, Zhe, Guan, Xin-Yuan, Zou, Chang, Fu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
GI cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762012/
https://www.ncbi.nlm.nih.gov/pubmed/33692094
http://dx.doi.org/10.1136/gutjnl-2020-322924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762012/
https://www.ncbi.nlm.nih.gov/pubmed/33692094
http://dx.doi.org/10.1136/gutjnl-2020-322924

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