Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo

OBJECTIVE: Therapeutic strategies silencing and reducing the hepatitis B virus (HBV) reservoir, the covalently closed circular DNA (cccDNA), have the potential to cure chronic HBV infection. We aimed to investigate the impact of small interferring RNA (siRNA) targeting all HBV transcripts or pegylat...

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Detalles Bibliográficos
Autores principales: Allweiss, Lena, Giersch, Katja, Pirosu, Andrea, Volz, Tassilo, Muench, Robert C, Beran, Rudolf K, Urban, Stephan, Javanbakht, Hassan, Fletcher, Simon P, Lütgehetmann, Marc, Dandri, Maura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762019/
https://www.ncbi.nlm.nih.gov/pubmed/33509930
http://dx.doi.org/10.1136/gutjnl-2020-322571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762019/
https://www.ncbi.nlm.nih.gov/pubmed/33509930
http://dx.doi.org/10.1136/gutjnl-2020-322571

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