Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus

OBJECTIVES: MAP4K3 (GLK) overexpression in T cells induces interleukin (IL)-17A production and autoimmune responses. GLK overexpressing T-cell population is correlated with severity of human systemic lupus erythematosus (SLE); however, it is unclear how GLK is upregulated in patients with SLE. METHO...

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Detalles Bibliográficos
Autores principales: Chuang, Huai-Chia, Hung, Wei-Ting, Chen, Yi-Ming, Hsu, Pu-Ming, Yen, Jeng-Hsien, Lan, Joung-Liang, Tan, Tse-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Systemic Lupus Erythematosus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762023/
https://www.ncbi.nlm.nih.gov/pubmed/34610951
http://dx.doi.org/10.1136/annrheumdis-2021-221010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762023/
https://www.ncbi.nlm.nih.gov/pubmed/34610951
http://dx.doi.org/10.1136/annrheumdis-2021-221010

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