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Effect of Trastuzumab–HER2 Complex Formation on Stress-Induced Modifications in the CDRs of Trastuzumab

Asparagine deamidation and aspartic acid isomerization in the complementarity determining regions (CDRs) of monoclonal antibodies may alter their affinity to the target antigen. Trastuzumab has two hot spots for deamidation and one position for isomerization in the CDRs. Little is known how complex...

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Detalles Bibliográficos
Autores principales: Spanov, Baubek, Aboagye, Victoria, Olaleye, Oladapo, Govorukhina, Natalia, van de Merbel, Nico C., Bischoff, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762049/
https://www.ncbi.nlm.nih.gov/pubmed/35047480
http://dx.doi.org/10.3389/fchem.2021.794247