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Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly

BACKGROUND: Elderly often show reduced immune functioning and can develop chronic low-grade inflammation. Why some elderly are more prone to become frail is unknown. We investigated whether frailty is associated with altered cytokine signaling through the JAK-STAT pathway in leukocytes of 34 individ...

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Detalles Bibliográficos
Autores principales:	Samson, Leonard Daniël, Engelfriet, Peter, Verschuren, W. M. Monique, Picavet, H. Susan J., Ferreira, José A., de Zeeuw-Brouwer, Mary-lène, Buisman, Anne-Marie, Boots, A. Mieke H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762193/ https://www.ncbi.nlm.nih.gov/pubmed/35039055 http://dx.doi.org/10.1186/s12979-021-00261-w

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