Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization

Purpose: The aims of this study were to establish a joint population pharmacokinetic model for voriconazole and its N-oxide metabolite in immunocompromised patients, to determine the extent to which the CYP2C19 genetic polymorphisms influenced the pharmacokinetic parameters, and to evaluate and opti...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, SiChan, Wu, SanLan, Gong, WeiJing, Cao, Peng, Chen, Xin, Liu, Wanyu, Xiang, Liping, Wang, Yang, Huang, JianGeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762230/
https://www.ncbi.nlm.nih.gov/pubmed/35046798
http://dx.doi.org/10.3389/fphar.2021.730826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762230/
https://www.ncbi.nlm.nih.gov/pubmed/35046798
http://dx.doi.org/10.3389/fphar.2021.730826

Ejemplares similares