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Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization

Purpose: The aims of this study were to establish a joint population pharmacokinetic model for voriconazole and its N-oxide metabolite in immunocompromised patients, to determine the extent to which the CYP2C19 genetic polymorphisms influenced the pharmacokinetic parameters, and to evaluate and opti...

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Detalles Bibliográficos
Autores principales:	Li, SiChan, Wu, SanLan, Gong, WeiJing, Cao, Peng, Chen, Xin, Liu, Wanyu, Xiang, Liping, Wang, Yang, Huang, JianGeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762230/ https://www.ncbi.nlm.nih.gov/pubmed/35046798 http://dx.doi.org/10.3389/fphar.2021.730826

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