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In silico Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium
Myocardial delivery of human c-kit(+) cardiac interstitial cells (hCICs) and human mesenchymal stem cells (hMSCs), an emerging approach for treating the failing heart, has been limited by an incomplete understanding of the effects on host myocardium. This computational study aims to model hCIC and h...
Autores principales: | Phillips, Katherine G., Turnbull, Irene C., Hajjar, Roger J., Costa, Kevin D., Mayourian, Joshua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762340/ https://www.ncbi.nlm.nih.gov/pubmed/35046835 http://dx.doi.org/10.3389/fphys.2021.755881 |
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