Overexpression of NMNAT3 improves mitochondrial function and enhances antioxidative stress capacity of bone marrow mesenchymal stem cells via the NAD(+)-Sirt3 pathway

Oxidative stress damage is a common problem in bone marrow mesenchymal stem cell (BMSC) transplantation. Under stress conditions, the mitochondrial function of BMSCs is disrupted, which accelerates senescence and apoptosis of BMSCs, ultimately leading to poor efficacy. Therefore, improving mitochond...

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Detalles Bibliográficos
Autores principales: Wang, Tao, Zhang, Fei, Peng, Wuxun, Wang, Lei, Zhang, Jian, Dong, Wentao, Tian, Xiaobin, Ye, Chuan, Li, Yanlin, Gong, Yuekun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cell Death & Injury
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762348/
https://www.ncbi.nlm.nih.gov/pubmed/34981121
http://dx.doi.org/10.1042/BSR20211005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762348/
https://www.ncbi.nlm.nih.gov/pubmed/34981121
http://dx.doi.org/10.1042/BSR20211005

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