Cargando…

Ultra-high-throughput Ca(2+) assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation

Antiplatelet drugs targeting G-protein-coupled receptors (GPCRs), used for the secondary prevention of arterial thrombosis, coincide with an increased bleeding risk. Targeting ITAM-linked receptors, such as the collagen receptor glycoprotein VI (GPVI), is expected to provide a better antithrombotic-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernández, Delia I., Provenzale, Isabella, Cheung, Hilaire Y.F., van Groningen, Jan, Tullemans, Bibian M.E., Veninga, Alicia, Dunster, Joanne L., Honarnejad, Saman, van den Hurk, Helma, Kuijpers, Marijke J.E., Heemskerk, Johan W.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762394/ https://www.ncbi.nlm.nih.gov/pubmed/35072010 http://dx.doi.org/10.1016/j.isci.2021.103718

Ejemplares similares

Multiparameter Evaluation of the Platelet-Inhibitory Effects of Tyrosine Kinase Inhibitors Used for Cancer Treatment
por: Tullemans, Bibian M. E., et al.
Publicado: (2021)

Hit Discovery for Public Target Programs in the European Lead Factory: Experiences and Output from Assay Development and Ultra-High-Throughput Screening
por: Honarnejad, Saman, et al.
Publicado: (2020)

Effects of Platelet Agonists and Priming on the Formation of Platelet Populations
por: Veninga, Alicia, et al.
Publicado: (2021)

Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro
por: Dickhout, Annemiek, et al.
Publicado: (2021)

Tyrosine Kinase Inhibitor Pazopanib Inhibits Platelet Procoagulant Activity in Renal Cell Carcinoma Patients
por: Tullemans, Bibian M. E., et al.
Publicado: (2018)

Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets
por: Kostyak, John C., et al.
Publicado: (2022)

Abundance of ITAM prevents autoimmunity
por: Robinson, Richard
Publicado: (2008)

RBP-J and ITAM crosstalk
por: Zhao, Baohong
Publicado: (2015)

Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces
por: Jooss, Natalie J., et al.
Publicado: (2019)

Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function
por: Tullemans, Bibian M.E., et al.
Publicado: (2021)

Protein C or Protein S deficiency associates with paradoxically impaired platelet‐dependent thrombus and fibrin formation under flow
por: Brouns, Sanne L. N., et al.
Publicado: (2022)

GPVI expression is linked to platelet size, age, and reactivity
por: Veninga, Alicia, et al.
Publicado: (2022)

Of ITAMs and ITIMs: turning on and off the B cell antigen receptor
Publicado: (1995)

TCR ITAM multiplicity is required for the generation of follicular helper T-cells
por: Hwang, SuJin, et al.
Publicado: (2015)

Contributions of the T Cell Receptor–associated CD3γ–ITAM to Thymocyte Selection
por: Haks, Mariëlle C., et al.
Publicado: (2002)

Quantitative and qualitative changes in platelet traits of sunitinib-treated patients with renal cell carcinoma in relation to circulating sunitinib levels: a proof-of-concept study
por: Tullemans, Bibian M. E., et al.
Publicado: (2022)

Localized endothelial‐based control of platelet aggregation and coagulation under flow: A proof‐of‐principle vessel‐on‐a‐chip study
por: Brouns, Sanne L.N., et al.
Publicado: (2020)

G6f-Like Is an ITAM-Containing Collagen Receptor in Thrombocytes
por: Hughes, Craig E., et al.
Publicado: (2012)

Selection and characterization of FcϵRI phospho-ITAM specific antibodies
por: Velappan, Nileena, et al.
Publicado: (2019)

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis
por: Li, Susan, et al.
Publicado: (2022)

Role of the ITAM-Bearing Receptors Expressed by Natural Killer Cells in Cancer
por: Medjouel Khlifi, Hakim, et al.
Publicado: (2022)

Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome
por: van Geffen, Johanna P., et al.
Publicado: (2020)

Retroviral Retention Activates a Syk-Dependent HemITAM in Human Tetherin
por: Galão, Rui Pedro, et al.
Publicado: (2014)

Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo
por: Bezman, Natalie A., et al.
Publicado: (2008)

An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells
por: Graham, Daniel B., et al.
Publicado: (2007)

Differential Requirements for Vav Proteins in DAP10- and ITAM-mediated NK Cell Cytotoxicity
por: Cella, Marina, et al.
Publicado: (2004)

Development and Initial Validation of the Italian Mood Scale (ITAMS) for Use in Sport and Exercise Contexts
por: Quartiroli, Alessandro, et al.
Publicado: (2017)

MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture
por: Katz, Elad, et al.
Publicado: (2005)

Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis
por: Guselnikov, S.V., et al.
Publicado: (2015)

Importance of Fc Receptor γ-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis
por: Németh, Tamás, et al.
Publicado: (2019)

Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding
por: Veninga, Alicia, et al.
Publicado: (2020)

Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation
por: Kuijpers, Marijke J. E., et al.
Publicado: (2022)

Phosphorylation of spleen tyrosine kinase at Y346 negatively regulates ITAM-mediated signaling and function in platelets
por: Dangelmaier, Carol A., et al.
Publicado: (2023)

Whole Blood Based Multiparameter Assessment of Thrombus Formation in Standard Microfluidic Devices to Proxy In Vivo Haemostasis and Thrombosis
por: Provenzale, Isabella, et al.
Publicado: (2019)

Bone Microenvironment Specific Roles of ITAM Adapter Signaling during Bone Remodeling Induced by Acute Estrogen-Deficiency
por: Wu, Yalei, et al.
Publicado: (2007)

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function
por: Falet, Hervé, et al.
Publicado: (2010)

Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice
por: Wolf, Karen, et al.
Publicado: (2016)

Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear
por: Hrdinova, Johana, et al.
Publicado: (2022)

Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
por: Zou, Wei, et al.
Publicado: (2007)

ITAM Signaling by Vav Family Rho Guanine Nucleotide Exchange Factors Regulates Interstitial Transit Rates of Neutrophils In Vivo
por: Graham, Daniel B., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_hemv1ukddmhut07gjj4nq1qqet