SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway

Heightened inflammatory response is a prominent feature of severe COVID-19 disease. We report that the SARS-CoV-2 ORF3a viroporin activates the NLRP3 inflammasome, the most promiscuous of known inflammasomes. Ectopically expressed ORF3a triggers IL-1β expression via NFκB, thus priming the inflammaso...

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Detalles Bibliográficos
Autores principales: Xu, Huanzhou, Akinyemi, Ibukun A., Chitre, Siddhi A., Loeb, Julia C., Lednicky, John A., McIntosh, Michael T., Bhaduri-McIntosh, Sumita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762580/
https://www.ncbi.nlm.nih.gov/pubmed/35066302
http://dx.doi.org/10.1016/j.virol.2022.01.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762580/
https://www.ncbi.nlm.nih.gov/pubmed/35066302
http://dx.doi.org/10.1016/j.virol.2022.01.003

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