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An integrative analysis of DNA methylation and transcriptome showed the dysfunction of MAPK pathway was involved in the damage of human chondrocyte induced by T-2 toxin

BACKGROUND: T-2 toxin is thought to induce the growth plate and articular cartilage damage of Kashin-Beck disease (KBD), an endemic osteochondropathy in China. This study aims to explore the potential underlying mechanism of such toxic effects by integrating DNA methylation and gene expression profi...

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Detalles Bibliográficos
Autores principales: Yang, Xuena, Xiao, Xue, Zhang, Lu, Wang, Bo, Li, Ping, Cheng, Bolun, Liang, Chujun, Ma, Mei, Guo, Xiong, Zhang, Feng, Wen, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762874/
https://www.ncbi.nlm.nih.gov/pubmed/35038982
http://dx.doi.org/10.1186/s12860-021-00404-3