The SF3B1(R625H) mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1

BACKGROUND: Recently, a hotspot mutation in prolactinoma was observed in splicing factor 3b subunit 1 (SF3B1(R625H)), but its functional effects and underlying molecular mechanisms remain largely unexplored. METHODS: Using the CRISPR/Cas9 genome editing system and rat pituitary GH3 cells, we generat...

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Detalles Bibliográficos
Autores principales: Guo, Jing, Li, Chuzhong, Fang, Qiuyue, Liu, Yulou, Wang, Dawei, Chen, Yiyuan, Xie, Weiyan, Zhang, Yazhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762886/
https://www.ncbi.nlm.nih.gov/pubmed/35039052
http://dx.doi.org/10.1186/s13046-022-02245-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762886/
https://www.ncbi.nlm.nih.gov/pubmed/35039052
http://dx.doi.org/10.1186/s13046-022-02245-0

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