Cargando…

The SF3B1(R625H) mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1

BACKGROUND: Recently, a hotspot mutation in prolactinoma was observed in splicing factor 3b subunit 1 (SF3B1(R625H)), but its functional effects and underlying molecular mechanisms remain largely unexplored. METHODS: Using the CRISPR/Cas9 genome editing system and rat pituitary GH3 cells, we generat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Jing, Li, Chuzhong, Fang, Qiuyue, Liu, Yulou, Wang, Dawei, Chen, Yiyuan, Xie, Weiyan, Zhang, Yazhuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762886/ https://www.ncbi.nlm.nih.gov/pubmed/35039052 http://dx.doi.org/10.1186/s13046-022-02245-0

Ejemplares similares

Somatic SF3B1 hotspot mutation in prolactinomas
por: Li, Chuzhong, et al.
Publicado: (2020)

Identifying critical protein-coding genes and long non-coding RNAs in non-functioning pituitary adenoma recurrence
por: Guo, Jing, et al.
Publicado: (2021)

Screening and Identification of Key Microenvironment-Related Genes in Non-functioning Pituitary Adenoma
por: Guo, Jing, et al.
Publicado: (2021)

A Novel Three-LncRNA Signature Predicting Tumor Recurrence in Nonfunctioning Pituitary Adenomas
por: Cheng, Sen, et al.
Publicado: (2021)

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
por: Harbour, J. William, et al.
Publicado: (2013)

Identification of a novel somatic mutation of POU6F2 by whole‐genome sequencing in prolactinoma
por: Miao, Yazhou, et al.
Publicado: (2019)

Identification of biomarkers associated with the invasion of nonfunctional pituitary neuroendocrine tumors based on the immune microenvironment
por: Wu, Jiangping, et al.
Publicado: (2023)

Lack of SF3B1 R625 mutations in cutaneous melanoma
por: Schilling, Bastian, et al.
Publicado: (2013)

JAG1, Regulated by microRNA-424-3p, Involved in Tumorigenesis and Epithelial–Mesenchymal Transition of High Proliferative Potential-Pituitary Adenomas
por: Chen, Yiyuan, et al.
Publicado: (2020)

Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors
por: Chen, Yiyuan, et al.
Publicado: (2020)

Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas
por: Gao, Hua, et al.
Publicado: (2015)

DICER1 mutation and pituitary prolactinoma
por: Cotton, Ellena, et al.
Publicado: (2018)

Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma
por: Hintzsche, Jennifer D., et al.
Publicado: (2017)

CDKN2A (p16(INK4A)) affects the anti-tumor effect of CDK inhibitor in somatotroph adenomas
por: Chen, Yiyuan, et al.
Publicado: (2021)

Analysis of the Prognostic and Immunological Role of HSPB1 in Pituitary Adenoma: A Potential Target for Therapy
por: Zhao, Sida, et al.
Publicado: (2023)

Global expression profile of tumor stem-like cells isolated from MMQ rat prolactinoma cell
por: Su, Zhipeng, et al.
Publicado: (2017)

Germline mutations in MEN1 are associated with the tumorigenesis of pituitary adenoma associated with meningioma
por: Zhu, Haibo, et al.
Publicado: (2020)

Recurrent hotspot SF3B1 mutations at codon 625 in vulvovaginal mucosal melanoma identified in a study of 27 Australian mucosal melanomas
por: Quek, Camelia, et al.
Publicado: (2019)

Genomic and transcriptomic analysis of pituitary adenomas reveals the impacts of copy number variations on gene expression and clinical prognosis among prolactin-secreting subtype
por: Chen, Yiyuan, et al.
Publicado: (2020)

Characterizing the Binding Sites for GK Domain of DLG1 and DLG4 via Molecular Dynamics Simulation
por: Li, Hongwei, et al.
Publicado: (2020)

Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts
por: Conte, Simona, et al.
Publicado: (2015)

A closer look at the synapse: dlg1[4K] enables cell-specific visualization of PSD-95/DLG1
por: Hendricks, Emily L., et al.
Publicado: (2023)

Use of micro-positron emission tomography with (18)F-fallypride to measure the levels of dopamine receptor-D2 and (18)F-FDG as molecular imaging tracer in the pituitary glands and prolactinomas of Fischer-344 rats
por: Li, Ping, et al.
Publicado: (2016)

The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development
por: Liu, Min, et al.
Publicado: (2016)

Splicing factor SF3B1(K700E) mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1
por: Jin, Shuiling, et al.
Publicado: (2017)

Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia
por: Uezato, A, et al.
Publicado: (2015)

Discs large (Dlg1) complexes in lymphocyte activation
por: Xavier, Ramnik, et al.
Publicado: (2004)

Quantitative analysis of Gria1, Gria2, Dlg1 and Dlg4 expression levels in hippocampus following forced swim stress in mice
por: Freudenberg, Florian
Publicado: (2019)

The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression
por: Huang, Yong, et al.
Publicado: (2020)

Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain
Publicado: (1996)

Long non-coding RNA C5orf66-AS1 is downregulated in pituitary null cell adenomas and is associated with their invasiveness
por: Yu, Guoqiang, et al.
Publicado: (2017)

Characterization of In Vivo Dlg1 Deletion on T Cell Development and Function
por: Humphries, Lisa A., et al.
Publicado: (2012)

Phosphorylation of kinase insert domain receptor by cyclin-dependent kinase 5 at serine 229 is associated with invasive behavior and poor prognosis in prolactin pituitary adenomas
por: Xie, Weiyan, et al.
Publicado: (2016)

PBK/TOPK Inhibitor Suppresses the Progression of Prolactinomas
por: Zhu, Kejing, et al.
Publicado: (2022)

Giant prolactinoma, germline BRCA1 mutation, and depression: a case report
por: Bettencourt-Silva, Rita, et al.
Publicado: (2018)

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
por: Alsafadi, Samar, et al.
Publicado: (2016)

Circ-DLG1 promotes the proliferation of esophageal squamous cell carcinoma
por: Rong, Jun, et al.
Publicado: (2018)

Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5
por: Li, Mingxuan, et al.
Publicado: (2021)

Mechanistic Insights of Aberrant Splicing with Splicing Factor Mutations Found in Myelodysplastic Syndromes
por: Kataoka, Naoyuki, et al.
Publicado: (2021)

Immune Checkpoints: Therapeutic Targets for Pituitary Tumors
por: Nie, Ding, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5fhp7oh331jbp4hbgn1addcn4o