Cargando…

Single-cell trajectories of melanoma cell resistance to targeted treatment

OBJECTIVE: Cellular heterogeneity is regarded as a major factor affecting treatment response and resistance in malignant melanoma. Recent developments in single-cell sequencing technology have provided deeper insights into these mechanisms. METHODS: Here, we analyzed a BRAF(V600E)-mutant melanoma ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmidt, Maria, Mortensen, Lena Sünke, Loeffler-Wirth, Henry, Kosnopfel, Corinna, Krohn, Knut, Binder, Hans, Kunz, Manfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Compuscript 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763000/ https://www.ncbi.nlm.nih.gov/pubmed/34591417 http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0267

Ejemplares similares

Melanoma Single-Cell Biology in Experimental and Clinical Settings
por: Binder, Hans, et al.
Publicado: (2021)

Pseudotime Dynamics in Melanoma Single-Cell Transcriptomes Reveals Different Mechanisms of Tumor Progression
por: Loeffler-Wirth, Henry, et al.
Publicado: (2018)

Developmental scRNAseq Trajectories in Gene- and Cell-State Space—The Flatworm Example
por: Schmidt, Maria, et al.
Publicado: (2020)

Mapping heterogeneity in patient-derived melanoma cultures by single-cell RNA-seq
por: Gerber, Tobias, et al.
Publicado: (2016)

A Transcriptome-Wide Isoform Landscape of Melanocytic Nevi and Primary Melanomas Identifies Gene Isoforms Associated with Malignancy
por: Hakobyan, Siras, et al.
Publicado: (2021)

Covid-19 Transmission Trajectories–Monitoring the Pandemic in the Worldwide Context
por: Loeffler-Wirth, Henry, et al.
Publicado: (2020)

Targeting Rad51 as a strategy for the treatment of melanoma cells resistant to MAPK pathway inhibition
por: Makino, Elena, et al.
Publicado: (2020)

The Human Blood Transcriptome in a Large Population Cohort and Its Relation to Aging and Health
por: Schmidt, Maria, et al.
Publicado: (2020)

Transcriptional states of CAR-T infusion relate to neurotoxicity – lessons from high-resolution single-cell SOM expression portraying
por: Loeffler-Wirth, Henry, et al.
Publicado: (2022)

Melanoma cells resistant towards MAPK inhibitors exhibit reduced TAp73 expression mediating enhanced sensitivity to platinum-based drugs
por: Makino, Elena, et al.
Publicado: (2018)

Human melanoma cells resistant to MAPK inhibitors can be effectively targeted by inhibition of the p90 ribosomal S6 kinase
por: Kosnopfel, Corinna, et al.
Publicado: (2017)

SOMmelier—Intuitive Visualization of the Topology of Grapevine Genome Landscapes Using Artificial Neural Networks
por: Nikoghosyan, Maria, et al.
Publicado: (2020)

The Transcriptome and Methylome of the Developing and Aging Brain and Their Relations to Gliomas and Psychological Disorders
por: Loeffler-Wirth, Henry, et al.
Publicado: (2022)

Integrated Multi-Omics Maps of Lower-Grade Gliomas
por: Binder, Hans, et al.
Publicado: (2022)

Classifying Germinal Center Derived Lymphomas—Navigate a Complex Transcriptional Landscape
por: Loeffler-Wirth, Henry, et al.
Publicado: (2022)

Transcriptomic Maps of Colorectal Liver Metastasis: Machine Learning of Gene Activation Patterns and Epigenetic Trajectories in Support of Precision Medicine
por: Ashekyan, Ohanes, et al.
Publicado: (2023)

The aging human body shape
por: Frenzel, Alexander, et al.
Publicado: (2020)

Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome
por: Hopp, Lydia, et al.
Publicado: (2018)

oposSOM-Browser: an interactive tool to explore omics data landscapes in health science
por: Loeffler-Wirth, Henry, et al.
Publicado: (2020)

Tumour Progression Stage-Dependent Secretion of YB-1 Stimulates Melanoma Cell Migration and Invasion
por: Kosnopfel, Corinna, et al.
Publicado: (2020)

Telomere Length Maintenance and Its Transcriptional Regulation in Lynch Syndrome and Sporadic Colorectal Carcinoma
por: Nersisyan, Lilit, et al.
Publicado: (2019)

The Evolving Faces of the SARS-CoV-2 Genome
por: Schmidt, Maria, et al.
Publicado: (2021)

Population Levels Assessment of the Distribution of Disease-Associated Variants With Emphasis on Armenians – A Machine Learning Approach
por: Nikoghosyan, Maria, et al.
Publicado: (2019)

Body typing of children and adolescents using 3D-body scanning
por: Loeffler-Wirth, Henry, et al.
Publicado: (2017)

Longitudinal anthropometry of children and adolescents using 3D-body scanning
por: Loeffler-Wirth, Henry, et al.
Publicado: (2018)

Epigenetic Heterogeneity of B-Cell Lymphoma: DNA Methylation, Gene Expression and Chromatin States
por: Hopp, Lydia, et al.
Publicado: (2015)

Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion
por: Kosnopfel, Corinna, et al.
Publicado: (2023)

Novel Anthropometry Based on 3D-Bodyscans Applied to a Large Population Based Cohort
por: Löffler-Wirth, Henry, et al.
Publicado: (2016)

"Hook"-calibration of GeneChip-microarrays: Chip characteristics and expression measures
por: Binder, Hans, et al.
Publicado: (2008)

Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies
por: Wolf, Johannes, et al.
Publicado: (2021)

Quantitative landscapes reveal trajectories of cell-state transitions associated with drug resistance in melanoma
por: Pillai, Maalavika, et al.
Publicado: (2022)

Portraying the Expression Landscapes of B-Cell Lymphoma-Intuitive Detection of Outlier Samples and of Molecular Subtypes
por: Hopp, Lydia, et al.
Publicado: (2013)

High-Resolution Cartography of the Transcriptome and Methylome Landscapes of Diffuse Gliomas
por: Willscher, Edith, et al.
Publicado: (2021)

Washing scaling of GeneChip microarray expression
por: Binder, Hans, et al.
Publicado: (2010)

Human Glioma–Initiating Cells Show a Distinct Immature Phenotype Resembling but Not Identical to NG2 Glia
por: Barrantes-Freer, Alonso, et al.
Publicado: (2013)

Transcriptome-Guided Drug Repositioning
por: Arakelyan, Arsen, et al.
Publicado: (2019)

Melanoma development: stage-dependent cancer competence of the melanocytic lineage
por: Kunz, Manfred
Publicado: (2021)

Epigenetic Heterogeneity of B-Cell Lymphoma: Chromatin Modifiers
por: Hopp, Lydia, et al.
Publicado: (2015)

Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
por: Su, Yapeng, et al.
Publicado: (2020)

Blood Eosinophils Are Associated with Efficacy of Targeted Therapy in Patients with Advanced Melanoma
por: Wendlinger, Simone, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_orlua758qahen1or3qbmvefbdj