Functional interaction between the RNA exosome and the sirtuin deacetylase Hst3 maintains transcriptional homeostasis

Eukaryotic cells maintain an optimal level of mRNAs through unknown mechanisms that balance RNA synthesis and degradation. We found that inactivation of the RNA exosome leads to global reduction of nascent mRNA transcripts, and that this defect is accentuated by loss of deposition of histone variant...

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Detalles Bibliográficos
Autores principales: Bryll, Alysia R., Peterson, Craig L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763048/
https://www.ncbi.nlm.nih.gov/pubmed/34916303
http://dx.doi.org/10.1101/gad.348923.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763048/
https://www.ncbi.nlm.nih.gov/pubmed/34916303
http://dx.doi.org/10.1101/gad.348923.121

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