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Functional interaction between the RNA exosome and the sirtuin deacetylase Hst3 maintains transcriptional homeostasis
Eukaryotic cells maintain an optimal level of mRNAs through unknown mechanisms that balance RNA synthesis and degradation. We found that inactivation of the RNA exosome leads to global reduction of nascent mRNA transcripts, and that this defect is accentuated by loss of deposition of histone variant...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763048/ https://www.ncbi.nlm.nih.gov/pubmed/34916303 http://dx.doi.org/10.1101/gad.348923.121 |