Guide RNA acrobatics: positioning consecutive uridines for pseudouridylation by H/ACA pseudouridylation loops with dual guide capacity

Site-specific pseudouridylation of human ribosomal and spliceosomal RNAs is directed by H/ACA guide RNAs composed of two hairpins carrying internal pseudouridylation guide loops. The distal “antisense” sequences of the pseudouridylation loop base-pair with the target RNA to position two unpaired tar...

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Detalles Bibliográficos
Autores principales: Jády, Beáta E., Ketele, Amandine, Moulis, Dylan, Kiss, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763049/
https://www.ncbi.nlm.nih.gov/pubmed/34916304
http://dx.doi.org/10.1101/gad.349072.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763049/
https://www.ncbi.nlm.nih.gov/pubmed/34916304
http://dx.doi.org/10.1101/gad.349072.121

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