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Guide RNA acrobatics: positioning consecutive uridines for pseudouridylation by H/ACA pseudouridylation loops with dual guide capacity
Site-specific pseudouridylation of human ribosomal and spliceosomal RNAs is directed by H/ACA guide RNAs composed of two hairpins carrying internal pseudouridylation guide loops. The distal “antisense” sequences of the pseudouridylation loop base-pair with the target RNA to position two unpaired tar...
| Autores principales: | , , , |
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| Format: | Online Artículo Texto |
| Sprog: | English |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2022
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| Fag: | |
| Online adgang: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763049/ https://www.ncbi.nlm.nih.gov/pubmed/34916304 http://dx.doi.org/10.1101/gad.349072.121 |