Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity

The regenerative potential of neural stem cells (NSCs) declines during aging, leading to cognitive dysfunctions. This decline involves up-regulation of senescence-associated genes, but inactivation of such genes failed to reverse aging of hippocampal NSCs. Because many genes are up-regulated or down...

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Detalles Bibliográficos
Autores principales: Kaise, Takashi, Fukui, Masahiro, Sueda, Risa, Piao, Wenhui, Yamada, Mayumi, Kobayashi, Taeko, Imayoshi, Itaru, Kageyama, Ryoichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763050/
https://www.ncbi.nlm.nih.gov/pubmed/34916302
http://dx.doi.org/10.1101/gad.349000.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763050/
https://www.ncbi.nlm.nih.gov/pubmed/34916302
http://dx.doi.org/10.1101/gad.349000.121

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