Guide RNA acrobatics: the one-for-two shuffle

RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of Genes & Development, Jády and colleagues (pp. 70–83) identify a novel mechanism...

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Detalles Bibliográficos
Autor principal: Meier, U. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763051/
https://www.ncbi.nlm.nih.gov/pubmed/35022325
http://dx.doi.org/10.1101/gad.349285.121
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author Meier, U. Thomas
author_facet Meier, U. Thomas
author_sort Meier, U. Thomas
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description RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of Genes & Development, Jády and colleagues (pp. 70–83) identify a novel mechanism by which a single guide RNA hairpin can specify two uridines adjacent to each other or separated by 1 nt; i.e., one for two or guide RNA acrobatics.
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spelling pubmed-87630512022-07-01 Guide RNA acrobatics: the one-for-two shuffle Meier, U. Thomas Genes Dev Outlook RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of Genes & Development, Jády and colleagues (pp. 70–83) identify a novel mechanism by which a single guide RNA hairpin can specify two uridines adjacent to each other or separated by 1 nt; i.e., one for two or guide RNA acrobatics. Cold Spring Harbor Laboratory Press 2022-01-01 /pmc/articles/PMC8763051/ /pubmed/35022325 http://dx.doi.org/10.1101/gad.349285.121 Text en © 2022 Meier; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by-nc/4.0/This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Outlook
Meier, U. Thomas
Guide RNA acrobatics: the one-for-two shuffle
title Guide RNA acrobatics: the one-for-two shuffle
title_full Guide RNA acrobatics: the one-for-two shuffle
title_fullStr Guide RNA acrobatics: the one-for-two shuffle
title_full_unstemmed Guide RNA acrobatics: the one-for-two shuffle
title_short Guide RNA acrobatics: the one-for-two shuffle
title_sort guide rna acrobatics: the one-for-two shuffle
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763051/
https://www.ncbi.nlm.nih.gov/pubmed/35022325
http://dx.doi.org/10.1101/gad.349285.121
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