Wolframin-1–expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice

Abnormally phosphorylated tau, an early neuropathologic marker of Alzheimer’s disease (AD), first occurs in the brain’s entorhinal cortex layer II (ECII) and then spreads to the CA1 field of the hippocampus. Animal models of tau propagation aiming to recapitulate this phenomenon mostly show tau tran...

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Detalles Bibliográficos
Autores principales: Delpech, Jean-Christophe, Pathak, Dhruba, Varghese, Merina, Kalavai, Srinidhi Venkatesan, Hays, Emma C., Hof, Patrick R., Johnson, W. Evan, Ikezu, Seiko, Medalla, Maria, Luebke, Jennifer I., Ikezu, Tsuneya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763211/
https://www.ncbi.nlm.nih.gov/pubmed/34524859
http://dx.doi.org/10.1126/scitranslmed.abe8455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763211/
https://www.ncbi.nlm.nih.gov/pubmed/34524859
http://dx.doi.org/10.1126/scitranslmed.abe8455

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