A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease

Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; however, barriers include uncertainty whether in vitro transcriptomic assays yield quantitative pharmacological data, o...

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Detalles Bibliográficos
Autores principales: Timmons, James A, Anighoro, Andrew, Brogan, Robert J, Stahl, Jack, Wahlestedt, Claes, Farquhar, David Gordon, Taylor-King, Jake, Volmar, Claude-Henry, Kraus, William E, Phillips, Stuart M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763401/
https://www.ncbi.nlm.nih.gov/pubmed/35037854
http://dx.doi.org/10.7554/eLife.68832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763401/
https://www.ncbi.nlm.nih.gov/pubmed/35037854
http://dx.doi.org/10.7554/eLife.68832

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