Heparan Sulfate Proteoglycans (HSPGs) Serve as the Mediator Between Monomeric Tau and Its Subsequent Intracellular ERK1/2 Pathway Activation

The conversion of soluble tau protein to insoluble, hyperphosphorylated neurofibrillary tangles (NFTs) is a major hallmark leading to neuronal death observed in neurodegenerative tauopathies. Unlike NFTs, the involvement of monomeric tau in the progression of tau pathology has been less investigated...

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Detalles Bibliográficos
Autores principales: Song, Liqing, Oseid, Daniel E., Wells, Evan A., Coaston, Troy, Robinson, Anne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763444/
https://www.ncbi.nlm.nih.gov/pubmed/35040015
http://dx.doi.org/10.1007/s12031-021-01943-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763444/
https://www.ncbi.nlm.nih.gov/pubmed/35040015
http://dx.doi.org/10.1007/s12031-021-01943-2

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