Cargando…

Irgm1 regulates metabolism and function in T cell subsets

Immunity Related GTPases (IRG) are a family of proteins produced during infection that regulate membrane remodeling events in cells, particularly autophagy and mitophagy. The human IRGM gene has been strongly associated with Crohn’s disease and other inflammatory diseases through Genome-Wide Associa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alwarawrah, Yazan, Danzaki, Keiko, Nichols, Amanda G., Fee, Brian E., Bock, Cheryl, Kucera, Gary, Hale, Laura P., Taylor, Gregory A., MacIver, Nancie J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763923/ https://www.ncbi.nlm.nih.gov/pubmed/35039539 http://dx.doi.org/10.1038/s41598-021-04442-x

Ejemplares similares

OR12-2 Obesity Induces Changes in T Cell Metabolism and Function
por: Alwarawrah, Yazan, et al.
Publicado: (2019)

Changes in Nutritional Status Impact Immune Cell Metabolism and Function
por: Alwarawrah, Yazan, et al.
Publicado: (2018)

Effects of T cell leptin signaling on systemic glucose tolerance and T cell responses in obesity
por: Kiernan, Kaitlin, et al.
Publicado: (2023)

Targeting T cell oxidative metabolism to improve influenza survival in a mouse model of obesity
por: Alwarawrah, Yazan, et al.
Publicado: (2020)

Targeting T cell (oxidative) metabolism to improve immunity to viral infection in the context of obesity
por: Greene, Elizabeth, et al.
Publicado: (2022)

SUN-649 Metabolic and Functional Regulation of T Cells by Insulin and Insulin like Growth Factor 1
por: Kiernan, Kaitlin, et al.
Publicado: (2020)

Effect of High-Intensity Interval Training on Rheumatoid Arthritis CD4+ T Cell Oxidative Metabolism
por: Andonian, Brian, et al.
Publicado: (2021)

The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease
por: Kiernan, Kaitlin, et al.
Publicado: (2021)

Role of T Cells in Malnutrition and Obesity
por: Gerriets, Valerie A., et al.
Publicado: (2014)

Regulation of Adaptive Immune Cells by Sirtuins
por: Warren, Jonathan L., et al.
Publicado: (2019)

Reproduction and Growth in a Murine Model of Early Life-Onset Inflammatory Bowel Disease
por: Nagy, Eniko, et al.
Publicado: (2016)

IRGM1 supports host defense against intracellular bacteria through suppression of type I interferon in mice
por: Rai, Prashant, et al.
Publicado: (2023)

Editorial: Nutritional Aspects of Immunity and Immunometabolism in Health and Disease
por: Karlsson, Erik A., et al.
Publicado: (2020)

IRGM in autophagy and viral infections
por: Petkova, Denitsa S., et al.
Publicado: (2013)

IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1(+/-) mice display increases atherosclerotic plaque stability
por: Fang, Shaohong, et al.
Publicado: (2021)

Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice
por: Rogala, Allison R., et al.
Publicado: (2018)

IRGM1 links mitochondrial quality control to autoimmunity
por: Rai, Prashant, et al.
Publicado: (2021)

Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium
por: Taylor, Gregory A., et al.
Publicado: (2020)

Death and Resurrection of the Human IRGM Gene
por: Bekpen, Cemalettin, et al.
Publicado: (2009)

Pediatric Giant Prolactinoma Presenting With Acute Obstructive Hydrocephalus and Intracranial Hypertension
por: Hendrix, Grace, et al.
Publicado: (2021)

Pediatric Giant Prolactinoma Presenting With Acute Obstructive Hydrocephalus and Intracranial Hypertension
por: Hendrix, Grace, et al.
Publicado: (2021)

Palmitoylation of the Immunity Related GTPase, Irgm1: Impact on Membrane Localization and Ability to Promote Mitochondrial Fission
por: Henry, Stanley C., et al.
Publicado: (2014)

Localisation and Mislocalisation of the Interferon-Inducible Immunity-Related GTPase, Irgm1 (LRG-47) in Mouse Cells
por: Zhao, Yang O., et al.
Publicado: (2010)

ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells
por: Luttman, Jillian Hattaway, et al.
Publicado: (2021)

Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease
por: Prescott, Natalie J., et al.
Publicado: (2010)

IRGM Variants and Susceptibility to Inflammatory Bowel Disease in the German Population
por: Glas, Jürgen, et al.
Publicado: (2013)

mSphere of Influence: Role of IRGM1 in Disease Control
por: Naik, Sumanta Kumar
Publicado: (2021)

Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis
por: Goswami, Apeksha Bharatgiri, et al.
Publicado: (2022)

Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice
por: Wilburn, Kaley M., et al.
Publicado: (2023)

Chaos analysis of EEG during isoflurane-induced loss of righting in rats
por: MacIver, M. B., et al.
Publicado: (2014)

Causación social
por: MacIver, R. M.
Publicado: (1942)

Abused inhalants enhance GABA-mediated synaptic inhibition
por: MacIver, M. Bruce
Publicado: (2009)

Consciousness and inward electromagnetic field interactions
por: MacIver, M. Bruce
Publicado: (2022)

IRGM Is a Common Target of RNA Viruses that Subvert the Autophagy Network
por: Grégoire, Isabel Pombo, et al.
Publicado: (2011)

Association of IRGM Polymorphisms and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast Iran
por: Bahari, Gholamreza, et al.
Publicado: (2012)

Autophagy-Related IRGM Polymorphism Is Associated with Mortality of Patients with Severe Sepsis
por: Kimura, Tomonori, et al.
Publicado: (2014)

Association of IRGM Gene Mutations with Inflammatory Bowel Disease in the Indian Population
por: Baskaran, Kirankumar, et al.
Publicado: (2014)

Association between IRGM polymorphisms and tuberculosis risk: A meta-analysis
por: Xie, Haojun, et al.
Publicado: (2017)

The role of ticagrelor in acute ischaemic stroke and high-risk TIA management
por: MacIver, Claire, et al.
Publicado: (2020)

Contribution of multi-modal imaging to our understanding of dystonia pathogenesis
por: MacIver, Claire, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_14kcpc0f0st7vq53el722q78td