Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing

Skeletal muscle tissue is severely affected in myotonic dystrophy type 1 (DM1) patients, characterised by muscle weakness, myotonia and muscle immaturity in the most severe congenital form of the disease. Previously, it was not known at what stage during myogenesis the DM1 phenotype appears. In this...

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Detalles Bibliográficos
Autores principales: Franck, Silvie, Couvreu De Deckersberg, Edouard, Bubenik, Jodi L., Markouli, Christina, Barbé, Lise, Allemeersch, Joke, Hilven, Pierre, Duqué, Geoffrey, Swanson, Maurice S., Gheldof, Alexander, Spits, Claudia, Karen, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Methods & Techniques
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764412/
https://www.ncbi.nlm.nih.gov/pubmed/35019138
http://dx.doi.org/10.1242/bio.058978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764412/
https://www.ncbi.nlm.nih.gov/pubmed/35019138
http://dx.doi.org/10.1242/bio.058978

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