Dual Effect: High NADH Levels Contribute to Efflux-Mediated Antibiotic Resistance but Drive Lethality Mediated by Reactive Oxygen Species

In light of the antibiotic crisis, emerging strategies to sensitize bacteria to available antibiotics should be explored. Several studies on the mechanisms of killing suggest that bactericidal antibiotic activity is enforced through the generation of reactive oxygen species (ROS-lethality hypothesis...

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Detalles Bibliográficos
Autores principales: Arce-Rodríguez, Alejandro, Pankratz, Debbie, Preusse, Matthias, Nikel, Pablo I., Häussler, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764520/
https://www.ncbi.nlm.nih.gov/pubmed/35038918
http://dx.doi.org/10.1128/mbio.02434-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764520/
https://www.ncbi.nlm.nih.gov/pubmed/35038918
http://dx.doi.org/10.1128/mbio.02434-21

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