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Lipoprotein-associated phospholipase A(2): A paradigm for allosteric regulation by membranes

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) associates with low- and high-density lipoproteins in human plasma and specifically hydrolyzes circulating oxidized phospholipids involved in oxidative stress. The association of this enzyme with the lipoprotein’s phospholipid monolayer to access...

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Detalles Bibliográficos
Autores principales: Mouchlis, Varnavas D., Hayashi, Daiki, Vasquez, Alexis M., Cao, Jian, McCammon, J. Andrew, Dennis, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764669/
https://www.ncbi.nlm.nih.gov/pubmed/34996868
http://dx.doi.org/10.1073/pnas.2102953118