Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8–mediated apoptosis of macrophages to promote lethal anthrax

Lethal toxin (LeTx)-mediated killing of myeloid cells is essential for Bacillus anthracis, the causative agent of anthrax, to establish systemic infection and induce lethal anthrax. The “LeTx-sensitive” NLRP1b inflammasome of BALB/c and 129S macrophages swiftly responds to LeTx intoxication with pyr...

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Detalles Bibliográficos
Autores principales: Van Hauwermeiren, Filip, Van Opdenbosch, Nina, Van Gorp, Hanne, de Vasconcelos, Nathalia, van Loo, Geert, Vandenabeele, Peter, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764678/
https://www.ncbi.nlm.nih.gov/pubmed/34996874
http://dx.doi.org/10.1073/pnas.2116415119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764678/
https://www.ncbi.nlm.nih.gov/pubmed/34996874
http://dx.doi.org/10.1073/pnas.2116415119

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