Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules

Microtubules (MTs) are polymers of αβ-tubulin heterodimers that stochastically switch between growth and shrinkage phases. This dynamic instability is critically important for MT function. It is believed that GTP hydrolysis within the MT lattice is accompanied by destabilizing conformational changes...

Descripción completa

Detalles Bibliográficos
Autores principales: LaFrance, Benjamin J., Roostalu, Johanna, Henkin, Gil, Greber, Basil J., Zhang, Rui, Normanno, Davide, McCollum, Chloe O., Surrey, Thomas, Nogales, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764682/
https://www.ncbi.nlm.nih.gov/pubmed/34996871
http://dx.doi.org/10.1073/pnas.2114994119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764682/
https://www.ncbi.nlm.nih.gov/pubmed/34996871
http://dx.doi.org/10.1073/pnas.2114994119

Ejemplares similares