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Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules
Microtubules (MTs) are polymers of αβ-tubulin heterodimers that stochastically switch between growth and shrinkage phases. This dynamic instability is critically important for MT function. It is believed that GTP hydrolysis within the MT lattice is accompanied by destabilizing conformational changes...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764682/ https://www.ncbi.nlm.nih.gov/pubmed/34996871 http://dx.doi.org/10.1073/pnas.2114994119 |