Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction

The protein tau and its isoforms are associated with several neurodegenerative diseases, many of which are characterized by greater deposition of the 4-repeat (4R) tau isoform; however, the role of 4R tau in disease pathogenesis remains unclear. We created antisense oligonucleotides (ASOs) that alte...

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Detalles Bibliográficos
Autores principales: Ezerskiy, Lubov A., Schoch, Kathleen M., Sato, Chihiro, Beltcheva, Mariana, Horie, Kanta, Rigo, Frank, Martynowicz, Ryan, Karch, Celeste M., Bateman, Randall J., Miller, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765054/
https://www.ncbi.nlm.nih.gov/pubmed/34874917
http://dx.doi.org/10.1172/jci.insight.152012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765054/
https://www.ncbi.nlm.nih.gov/pubmed/34874917
http://dx.doi.org/10.1172/jci.insight.152012

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