Deficiency of lncRNA SNHG12 impairs ischemic limb neovascularization by altering an endothelial cell cycle pathway

SNHG12, a long noncoding RNA (lncRNA) dysregulated in atherosclerosis, is known to be a key regulator of vascular senescence in endothelial cells (ECs). However, its role in angiogenesis and peripheral artery disease has not been elucidated. Hind-limb ischemia studies using femoral artery ligation (...

Descripción completa

Detalles Bibliográficos
Autores principales: Gross, David A., Cheng, Henry S., Zhuang, Rulin, McCoy, Michael G., Pérez-Cremades, Daniel, Salyers, Zachary, Wara, A.K.M. Khyrul, Haemmig, Stefan, Ryan, Terence E., Feinberg, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765056/
https://www.ncbi.nlm.nih.gov/pubmed/34793334
http://dx.doi.org/10.1172/jci.insight.150761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765056/
https://www.ncbi.nlm.nih.gov/pubmed/34793334
http://dx.doi.org/10.1172/jci.insight.150761

Ejemplares similares